Progesterone and neuroprotection

Progesterone and neuroprotection

Progesterone is a very important hormone for the body functions of men and women. In women, ovaries form this hormone after ovulation, which plays an important role for preparing the body for menstrual cycle, pregnancy and conception. Progesterone helps preserve the uterine lining and prevents contractions that can cause an initial abortion when fertilized. In addition to progesterone reproduction, emotional stability, immune response affects metabolism and bone health. Women usually develop osteoporosis after menopause shows how important the role of progesterone is for bone health. It helps in controlling inflammation, controls sleep, and has worrying (anti -anxiety) properties. Progesterone is produced by the testicular and adrenal glands in men, but in lesser amounts than women. It affects sperm growth, testosterone synthesis and hormonal balance in general. In men, progesterone also supports heart health, mood stability and brain function. It supports normal hormonal balance by reducing the effects of additional estrogen.

Progesterone plays an important role in preserving brain function and helping to treat nerve damage. It acts as an anti-inflammatory agent, reduces the generation of toxic cytokines and increases overraction from the immune system that can damage neurons. This ability to control inflammation is quite important in diseases such as painful brain damage, stroke and neurodynative diseases, such as Alzheimer's disease. Progesterone reduces neuronal loss by regulating inflammatory reactions. This article "Brain-technical neurotrophic factors and related mechanisms that of mediation and affected progesterone-induced neuroprootection" by Mehravan Singh and colleagues discover neuroprotective properties of progesterone, which is especially in the connection of the brain-oriented neurotrophic factor (brain. " The material, which emphasizes the function of progesterone in a wide variety of neurological conditions, is in relation to the subject, including painful brain injury (TBI) and its potential neuroprottive properties.

The article "brain-technical neurotrophic factors and related mechanisms that mediate and affect progesterone-inspired neuroprooteten" emphasizes how important BDNF is for neurological survival, synaptic plasticity and brain health maintenance. Similarly, the progesterone article explains how progesterone therapy is linked to high level of neurotrophic factors, such as BDNF, which promotes neuroproote after trauma such as painful brain injury. The level of progesterone-inspired elevated BDNF gives the benefits of survival to neurons by activating TRKB receptors, which affects routes including PI3/AKT and ERK/Mapk, which are important for cellular survival and repair.

Progesterone receptor (PR) activation and neuro steroidogenesis as well as effects on neuronal function are just a couple of examples of progesterone modes of action as they occur according to the first article. Additionally, interactions reviewed within the context of BDNF roles' regulation, wherein levels of expression of the neurotrophin play a decisive role, could be linked with hypothesized engagement of certain microRNAs acting on the adjustment to progesterone treatment.

The therapeutic value of progesterone therapy for neurological conditions, such as TBI and neurodegenerative diseases, is highlighted in the two articles. The review puts forward that depending on how each progestin acts on BDNF and certain receptor types, different progestins can provide different results. Further research on the complicated interactions with BDNF and other signaling pathways must be conducted, as the original article also mentions the lack of clinical effectiveness in the use of progesterone for TBI despite encouraging results in animal models.

In summary, both papers are in agreement that progesterone is extremely promising as a neuroprotectant, which is very much mediated by BDNF and other neurotrophic processes. They offer a scientifically reasonable explanation of progesterone's role in brain health bringing reproductive biology to bear on essential neuroprotective properties and suggesting potential future therapeutic uses for neurological diseases. The relationship renders requisite justification for arguing that improvement of progesterone-derived treatments requires knowledge of the very mechanisms and processes engaged, such as the action of neurotrophins like BDNF.

References:

Theis, Verena, and Carsten Theiss. “Progesterone Effects in the Nervous System.” Anatomical record (Hoboken, N.J. : 2007) vol. 302,8 (2019): 1276-1286. doi:10.1002/ar.24121 

Singh, Meharvan et al. “Brain-derived neurotrophic factor and related mechanisms that mediate and influence progesterone-induced neuroprotection.” Frontiers in endocrinology vol. 15 1286066. 26 Feb. 2024, doi:10.3389/fendo.2024.1286066