Wednesday, May 1, 2024
Suffering from Memory Loss...But Maybe not for Long.
The Potential of Art Therapy with Alzheimer's Disease
In the world of Alzheimer's disease (AD), pharmacological options often fall short and or are invasive to the patient. However, non-pharmacological interventions such as art therapy are gaining popularity and showing promise. Art therapy engages cognitive and emotional faculties which can potentially offer support for individuals suffering from AD. The underlying mechanism at work remains unknown but focusing on certain parts of the brain may reveal some things.
In the research article, "Cerebellar
EEG source localization reveals age-related compensatory activity moderated by
genetic risk for Alzheimer's disease" the researchers delved into the
relationship between age and genetic risk factors for AD. Particularly they
focused on the role of the cerebellum in executive functioning using EEG data.
Previous studies showed that individuals who are aging have signs of
compensatory brain activity to help maintain proper function. The researchers
of this study found that older age predicts greater cerebellar activity during
inhibitory tasks which shows that there is a compensatory role for AD in the
cerebellum. The issue arises because there is only a finite amount of
compensatory capacity available and it depletes faster in those who carry the
APOE4 allele. This means individuals with this gene are more at risk of having
an earlier impact on their cerebellar function than those without it the risk
factor when aging. In particular, the posterior cerebellum activation during
the inhibitory test is in line with pre-existing research. Previous research
has shown crus 1 and 2 are vulnerable to age-related Alzheimer development
which are located in the posterior portion of the cerebellum. This also
indicates potential early impacts on cerebellar function for individuals at
risk of AD. Individuals suffering from AD have bouts of anxiety or
uncontrollable agitation that have usually been met with medical treatment
which leaves the patients more doicle a less responsive state.
In the research review "Creative Art
Therapy as a Non-Pharmacological Intervention for Dementia." The
researchers were able to give insight into the effectiveness and efficacy of
art therapy for those with AD. They explain the importance of having
alternative interventions for dementia and art therapy offers a holistic
approach to managing behavioral and psychological symptoms of dementia (BPSD)
that were unknown before. Art therapy allows individuals living with AD to
express their emotions and cope with the cognitive challenges they face on an
everyday basis. Having patients facilitate a more interpersonal connection with
their caregivers and giving them a sense of living in the moment helps reduce
agitation and anxiety which keeps their mood in balance. Art therapy is
especially helpful with dementia patients because of the concept of
person-centered care. Each person living with AD has unique needs and
preferences and using art helps to tailor a more personal experience for each
person, this helps promote a sense of belonging and lets them share their
experience. Art therapy not only supports emotional well-being but also helps
promote cognitive function in the brain. Art therapy can have an indirect
effect on the cerebellum, engaging in creative activities stimulates neural
networks that regulate emotional attention and motor control.
Connecting the two studies we can come to
the conclusion that observable improvements in the quality and overall
well-being of life for individuals suffering from AD can be mediated by changes
in the cerebral activity induced by art therapy. The genetic difference
observable from the first study goes to show the importance of having unique
and personalized patient care instead of having pharmacological interventions
at the cost of the patient. Both studies talk about the importance of having
nonpharmacological interventions and the need for a greater understanding of
the underlying mechanism of AD, but by using the power of creative expression
with the neural underpinnings we are discovering, we will be able to help the
well-being of dementia patients.
References:
Emblad, Shayla Y M, and Elizabeta B
Mukaetova-Ladinska. “Creative Art Therapy as a Non-Pharmacological Intervention
for Dementia: A Systematic Review.” Journal
of Alzheimer’s Disease Reports,
U.S. National Library of Medicine, 3 May 2021,
www.ncbi.nlm.nih.gov/pmc/articles/PMC8203286/#sec0005title.
Paitel, E. R.,
& Nielson, K. A. (2023). Cerebellar EEG source
localization reveals age-related compensatory activity moderated by genetic
risk for Alzheimer's disease. Psychophysiology, 60, e14395. https://doi.org/10.1111/psyp.14395
Cramming for an Exam? Bring out Beethoven!
Music has existed since the dawn of humanity…it serves as a form of social connection, expression of creativity and identity, cultural statement, and much more. In more recent decades, the link between music, learning, and memory has started to be explored in the study of neuroscience. As Dr. Dye touched on in our neuroscience seminar, playing an instrument has been proven to promote neuroplasticity all the way through older age; Even playing an instrument as a young adult can positively impact one’s memory, sound processing ability, and attention at age 65. After learning about these astonishing benefits, I wondered about the short term effects of just listening to music rather than playing it. Especially as I enter finals week, I am curious about the validity of study tips asserting that classical music can help one retain information for exams. The research article Classical music, educational learning, and slow wave sleep: A targeted memory reactivation experiment by Chenlu Gao, Paul Fillmore, and Michael K Scullin explores the impact of classical music on targeted memory reactivation, or TMR.
The 50 college-aged participants (ages 18-33) listened to pieces by Chopin, Beethoven, and Vivaldi while studying a microeconomics lecture and then either control noise or the same piano pieces during slow wave sleep. Half of the participants listened to the piano music being replayed while they slept (TMR condition), while the other half listened to white noise. Broadly, the results showed that the students in the TMR condition scored about 18% higher on their microeconomics test on the lecture material the next day compared to the students who listened to the white noise. The researchers suggested that this result occurred due to the music pairing, asserting that repeating the same pieces by Chopin, Beethoven, and Vivaldi stimulated the brain to consolidate memories of the information more efficiently. This reminds of similar phenomena, like when the scent of flowers or bread can bring one back to a specific memory or time.
Spectral analysis performed during the study also indicated that during slow wave sleep there was a notable increase in the frontal theta activity, a type of neural electrical pulse that is thought to play a role in information consolidation, processing, creativity, and memories. Theta activity is usually seen when the brain is in a relaxed state, like sleeping, meditation, or daydreaming. Following this logic, greater frontal theta activity could help protect against forgetting information from the microeconomics lecture, and increase memory consolidation related to higher scores on the exam. Essentially, the researchers successfully primed the students in the TMR condition to perform 18% better on the exam by simply playing the piano music as they slept and promoting heightened frontal lobe activity through doing so.
However, it is important to note that there was no significant disparity observed between the TMS and white noise groups during the follow up assessment conducted 9 months later. Both cohorts dropped down to baseline knowledge levels that matched their pretest scores. This indicates that the experimentally consolidated memories were no more resistant to long term forgetting compared to the control group. Further research could explore methods to promote long term memory retention through listening to music, as this experiment only showed benefits between listening to music while studying and its subsequent impact on next-day exam performance. As the semester nears its end for me and my fellow college students, this research expanding on the benefits of music through the lens of neuroscience offers intriguing study recommendations. For those cramming the night before an exam, consider incorporating classical music into your study routine and continue listening to the same pieces while you sleep. The potential 18% boost in performance the next day could be worth it.
Gao, C., Fillmore, P., & Scullin, M. K. (2020). Classical music, educational learning, and slow wave sleep: A targeted memory reactivation experiment. Neurobiology of learning and memory, 171, 107206. https://doi.org/10.1016/j.nlm.2020.107206
Can Piano Lessons Be Key to Preventing Dementia?
Dementia is used to describe things like the loss of memory, problem-solving, and more. There are many types of dementia like Alzheimer’s, Vascular Dementia, and more. The damage to the brain cells causes this. Different types of brain cell damage are associated with different types of dementia. For example, in Alzheimer’s, a build-up of protein can prevent brain cells from communicating with each other. There are risk factors for dementia like age and genetics and age, however, those are factors that cannot be changed easily. So the question of how can we combat against getting disorder arises. The practice of music has been a topic of interest in preventing dementia.
In Nina Kraus and Travis White-Schwoch’s article “The Argument for Music Education” different articles imply that there is a connection between playing an instrument and neuroplasticity, which is how the brain changes to what it is going through, like when we learn something for example, the wiring of our brain can change in response to that. In the news article, “Can Playing an instrument help protect you from Dementia?” A study found that people who were 40 and older and had played an instrument or even sang had better executive function. These activities could be a way to preserve brain health in people, especially in light of diseases like dementia. In another article, “Can Music help train our brains to delay cognitive decline” they discussed a study by which intensive music playing can slow down the loss of gray matter in the brain so that it can maintain its plasticity, by doing this, it is possible to prevent the brain from degenerating.
With all these benefits from playing music, it can help to prevent our brain from degenerating and for it to be strong, and there are many other benefits as well. More research is to be don on this connection.
Works Cited:
Berman, Robby. “Cognitive Decline: Can Practicing Music Help Prevent It?” Medical News Today, MediLexicon International, www.medicalnewstoday.com/articles/can-music-help-train-our-brains-to-delay-cognitive-decline#Differences-between-playing-and-listening-to-musi. Accessed 1 May 2024.
Marshall, Mallika. “Can Playing an Instrument Help Protect You from Developing Dementia?” CBS News, CBS Interactive, 5 Feb. 2024, www.cbsnews.com/boston/news/playing-an-instrument-developing-dementia-university-of-exeter/
Garrison, Amelia. “How Music Prevents Cognitive Decline.” Pacific Neuroscience Institute, 18 Jan. 2022, www.pacificneuroscienceinstitute.org/blog/alzheimers-disease/how-music-prevents-cognitive-decline/
“What Is Dementia?” Alzheimer’s Disease and Dementia, www.alz.org/alzheimers-dementia/what-is-dementia. Accessed 1 May 2024.
Happiness From a Neural Perspective
What exactly is happiness? This term, although popularly used, doesn’t have a subjective meaning as its definition is extremely subjective. Nevertheless, we all strive to be “happy”, whatever that may mean for each individual. According to the Britannica Dictionary, “Happiness in psychology, a state of emotional well-being that a person experiences either in a narrow sense, when good things happen in a specific moment, or more broadly, as a positive evaluation of one’s life and accomplishments overall—that is, subjective well-being”(Britannica). This brings the question of how we can cultivate a positive evaluation of our lives? With various mental illnesses such as depression or anxiety on the rise, it is crucial to ask these questions so that our society can understand how to halt this rapid increase. Working towards one’s ultimate goal of happiness is not an easy feat, but neuroscientists and psychologists have investigated the functional neuroanatomy of happiness and pleasure. Allowing people to take a scientific route of understanding happiness and work towards potential theories can be groundbreaking for the mental wellbeing of many.
Mental health appears to be such a strong priority in the United States, yet, it remains a significant struggle for many. Upon being diagnosed, people often still go through relapses and struggle with issues such as depression. In “ Regulating Positive Emotions: Implications for Promoting Well-Being in Individuals With Depression”, researchers looked into potentially shifting the focus of depression therapy to include focusing on the regulation of positive emotions. Individuals with depression often deal with issues regulating both their positive and negative emotions, yet therapy mainly focuses on negative emotion regulation. So what about positive emotional regulation? The article discusses how a key factor of being happy is being able to regulate positive emotions, as the various benefits that come with being emotionally positive include improved levels of, “sleep quality, increased exercise, and lower levels of cortisol as well as decreased levels of depression and pain resilience” (Silton et al. 93). Research has pointed towards a lack of positive emotional regulation resulting in a lack of “frequency, duration, intensity, and quality of positive emotions” (Silton et al. 94). The impact of understanding how to regulate one’s positive emotions is dramatic, with it having polar effects when included versus not included. So what is the science behind emotional regulation and being an overall happier individual?
Being happy often is a complex emotion, with part of it dealing with a lack of negative emotion and the other aspect dealing with an influx of positive emotion. In the study “The Neuroscience of Happiness and Pleasure”, researchers have driven into what networks of the brain and involved neurotransmitters contribute to an increase of positive emotion. Two highly relevant factors to one’s happiness in cognitive terms are their levels of reward and pleasure. There are a handful of brain circuits that are associated with an individual's reward and pleasure levels, some being the OFC, ACC, NAc, and amygdala. Although the brain has an extensive array of circuitry that deals with one’s reward level, there are not nearly as many mechanisms involved. Scattered throughout the brain are “hedonic hotspots'' that generate positive reactions to pleasures. These hotspots are found in the “nucleus accumbens shell and ventral pallidum, and possibly other forebrain and limbic cortical regions, and also in deep brainstem regions, including the parabrachial nucleus in the pons'' (Kringelbach and Berridge). Research also points to the midanterior subregion of the orbitofrontal cortex as a significant coder of the pleasure experience. Although researchers have not been able to clearly discover all of the brain regions that are essential for pleasure that get disrupted by anhedonia, there is a possibility that the ventral pallidum may be linked to a lack of happiness and pleasure. Researchers have gotten to this conclusion through conducting studies whereas a result of damage to the ventral pallidum, one’s capacity for positive hedonic reactions was abolished (Kringelback and Berridge). Now that we understand key factors of maintaining one’s happiness as well as the science behind it, how can we implement methods in treatment and in our daily lives to cultivate more happiness?
Savoring is key. Savor the moments of love in your lives. Savor the moments of happiness in your lives. Savor the bright moments of your lives. By properly savoring positive moments in one’s life, there can be more happiness cultivated from a single moment, allowing someone to fully absorb the positive energy. In the reading, “Regulating Positive Emotions: Implications for Promoting Well-Being in Individuals With Depression”, the researchers discuss how savoring moments goes hand in hand with “poly regulation and can involve activating a variety of cognitive and behavioral emotion regulation strategies (e.g., amplification or positive rumination) that increase frequency, intensity, and duration of positive feelings” (Silton et al. 94). By increasing positive feelings, one can decrease emotions that deal with anhedonia, which can lead people to reaching higher happiness levels as a whole. Savoring can be practiced in various ways, with people savoring moments through sharing with others, congratulating oneself, building memories, expressing behaviors, counting blessings, expressing behavior, and avoiding killjoy thinking (Silton et al. 95). By savoring moments, one is able to enjoy the sweetness of a happy moment and therefore continue to generate more positive reactions to the pleasures of life. Through working to savor moments in one’s life, an individual can develop better savoring skills, leading to an overall decrease of negative emotions. The presented reading also suggests other methods of increasing one’s happiness levels, one being mindful meditation practices. Research points to the practice of mindful meditation resulting in an increased capacity for positive emotions. Mindfulness is theorized to help increase positive emotions through broadening “cognitive scope, which in turn bolsters the capacity for savoring” (Silton et al. 95). Next time you are experiencing an amazing day, make sure to savor it. If your day frees up and you have extra time, take a moment to slow down and meditate. Incorporating these steps into a lifestyle allows us to take in the world more and as a result, increased positive emotions will stem.
As we continue to look towards understanding happiness more and work to achieve our goals of happiness, it is important to implement these methods on one’s lifestyle. Although happiness does not have a subjective definition, we are all human beings that strive towards positivity in our lives. Learning more about the processes that underlie happiness from a neuronal perspective gives us the opportunity not only to understand ourselves more but also achieve mental health goals quicker and easier.
Resources:
Kringelbach, M. L., & Berridge, K. C. (2010). The Neuroscience of Happiness and Pleasure. Social research, 77(2), 659–678.
Silton, R. L., Kahrilas, I. J., Skymba, H. V., Smith, J., Bryant, F. B., & Heller, W. (2020). Regulating positive emotions: Implications for promoting well-being in individuals with depression. Emotion, 20(1), 93–97. https://doi.org/10.1037/emo0000675
Cultivating Positive Emotions for Better Health and Well-Being
Dr. Silton’s presentation provided a fascinating exploration of the importance of positive emotion regulation, particularly in individuals struggling with depression. I found her research and explanations to be engaging and inspiring. Dr. Silton’s work not only focuses on the significance of positive emotions for overall well-being, but also offers practical strategies for cultivating these emotions. Do you tend to see the glass half full or half empty? The way we perceive the world around us can have a significant impact on our health and well-being. Recent research suggests that cultivating positive emotions can benefit not only our mental state, but also our physical health. In a recent article, researchers explored the links between positive emotions and overall health. They found that individuals with a more positive outlook tend to have lower blood pressure, reduced risk for heart disease, healthier weight, better blood sugar levels, and even longer life spans. But what does it mean to have a positive outlook? Dr. Barbara L. Fredrickson, a psychologist, explains that it does not mean you never experience negative emotions. Instead, it is about finding a balance between positive and negative emotions. Positive emotions like joy, gratitude, and contentment can broaden our awareness and help us grow, while negative emotions can be adaptive in the short term, helping us navigate difficult situations. One of the key components of emotional wellness is resilience–the ability to bounce back from challenges. People who are emotionally well tend to have fewer negative emotions and can hold onto positive emotions longer, appreciating the good times. They also often have a sense of meaning and purpose in life. But how exactly do positive emotions affect our health? Dr. Richard J. Davidson, a neuroscientist, explains that positive emotions can trigger reward pathways in the brain, leading to feelings of well-being. Continued activation of these pathways has been linked to healthful changes in the body, including lower levels of stress hormones. On the other hand, negative emotions can activate areas of the brain associated with fear and anxiety. Individuals who have difficulty recovering from negative emotions may be at higher risk for various health conditions. Research suggests that we can cultivate positive emotions through various practices. Meditation, cognitive therapy, and self-reflection have all been shown to help develop the skills needed to make positive, healthful changes in our lives. For example, studies have found that practicing compassion and kindness meditation can lead to increased positive emotions and social connectedness. In another study, self-affirmation–a process of reflecting on what’s most important to you–was shown to activate reward pathways in the brain. This activation can lead to positive, healthful behaviors, such as becoming more physically active. So, how does all of this relate to individuals with depression? Dr. Silton’s article Regulating Positive Emotions: Implications for Promoting Well-Being in Individuals With Depression explores the importance of positive emotion regulation in mental health. While depression is often characterized by anhedonia–a lack of pleasure–research suggests that individuals with depression can benefit from learning to regulate positive emotions. By practicing techniques like savoring positive experiences, cultivating mindfulness, and engaging in self-affirmation, individuals with depression can develop the skills needed to experience more positive emotions. This, in turn, can lead to improved mental and physical health outcomes. In conclusion, the research is clear: cultivating positive emotions is essential for our overall health and well-being. By finding a balance between positive and negative emotions and practicing techniques to enhance our emotional wellness, we can lead happier, healthier lives. Remember, as Dr. Fredrickson says, “We can have some control over which emotions we experience.” So, why not choose to focus on the positive?