In a recent seminar presentation at Loyola University Chicago, Dr. Nicholas Baker discussed his research regarding the efficacy of deep convolutional neural networks (DCNNs) in matching human object recognition and visual processing patterns (Baker & Elder, 2022). The goal of the study was to assess DCNN image identification performance upon exposure to known and distorted shapes. Similarities in human and DCNN response accuracy would provide insight into whether DCNNs process visual information in the same way as the mammalian brain. The results of the study yielded several observations. First, humans and DCNNs both identified non-manipulated shapes with a high degree of accuracy, but demonstrated impaired identification performance for fragmented shapes. Humans and DCNNs also encountered “frankenstein” configurations, wherein the spatial arrangement of features were disrupted but the images remained whole. While humans had difficulty in this condition, DCNNs did not portray any deficiency. Accordingly, Dr. Baker explained that DCNNs rely on local shape cues, whereas humans integrate spatial information to derive overall meaning. This “small detail” versus “big picture” discrepancy highlights fundamental differences in how DCNNs and humans understand and interpret visual stimuli.
Despite these findings, artificial intelligence technologies have proven useful in other areas of neuroscience; they may even have important healthcare implications. Two different studies, for instance, have investigated the use of AI as a diagnostic tool for dementia and Alzheimer's disease. In one randomized clinical trial, Boustani et al. paired the Quick Dementia Rating System (QDRS) with an AI passive digital marker, programmed to extract information from electronic health records (Boustani et al., 2025). In clinics that employed the QDRS and PDM, the rate of new Alzheimer’s diagnoses increased by 31%. Given that around 50% of adults do not receive official diagnoses, this study presents one way artificial intelligence can easily be used to improve early detection.
A different team at UCLA has employed AI technologies to reduce racial bias in Alzheimer’s disease diagnoses. Prior research has revealed that diagnosis rates among non-white individuals fail to match up to higher relative prevalence rates, indicating that under-detection is pervasive in minority populations (Tran et al., 2025). The semi-supervised positive unlabeled learning (SSPUL) model was able to identify undiagnosed individuals with Alzheimer’s and demonstrated higher sensitivity than other AI technologies. Additionally, results provided by SSPUL were not altered when race and ethnicity data were changed, indicating low comparative racial bias. These findings are significant in regards to “catching” Alzheimer’s cases that would have otherwise gone undiscovered.
Overall, what do these studies reveal about humans and AI? Dr. Baker’s research emphasizes that the human brain is enormously complex. We might still be quite far out from developing technology that accurately mirrors the complexity of human neural processing. Human propensities toward mistakes and bias, however, emphasize that there are benefits to not having AI think like us. As AI technologies continue to advance, they hold potential for massive healthcare implications, including Alzheimer’s diagnoses and beyond. AI technologies process information differently than humans, and thus have the capacity to fill in the gaps that humans have left open.
References
Baker, N., & Elder, J. H. (2022). Deep learning models fail to capture the configural nature of human shape perception. iScience, 25(9), 104913. https://doi.org/10.1016/j.isci.2022.104913
Boustani, M. A., Ben Miled, Z., Owora, A. H., Fowler, N. R., Dexter, P., Puster, E., Grout, R. W., Summanwar, D., Erazo, S. F., Disla, S., Coppedge, K., & Galvin, J. E. (2025). Digital detection of dementia in primary care. JAMA Network Open, 8(11). https://doi.org/10.1001/jamanetworkopen.2025.42222
Tran, T., Fu, M., Fung, J., Sankararaman, S., Elashoff, D. A., Vossel, K., & Chang, T. S. (2025). Fair positive unlabeled learning for predicting undiagnosed Alzheimer's disease in diverse electronic health records. Npj Digital Medicine, 8(1). https://doi.org/10.1038/s41746-025-02111-1