Sunday, December 8, 2019

Neuromodulation of Aggressiveness in Violent Offenders


In a 2019 study published in the journal Neuroscience, Andrés Molero-Chamizo of the University of Huelva, Spain acted as the lead researcher examining the effects of anodal transcranial direct current stimulation (tDCS) on self-reported aggressiveness in prisoners with violent offenses. tDCS is a non-invasive, painless form of neurostimulation in which electrodes placed on the head deliver a low-intensity electrical current to a specific part of the brain. Anodal tDCS refers to the excitation of neuronal activity, whereas cathodal tDCS inhibits neuronal activity. In this particular study, Molero-Chamizo and his team of researchers applied anodal tDCS stimulation bilaterally to the prefrontal cortex. They chose to activate this area of the brain because reduced activity in the prefrontal cortex has been associated with aggression and violence. The researchers split their 41 male participants into two groups: 15 murderers and 26 non-murderers. The researchers had the participants fill out the Buss-Perry Aggression Questionnaire (BAQ) before and after their tDCS treatments. The questionnaire asks participants how much they agree with statements such as, “Sometimes I fly off the handle for no good reason.” The tDCS was applied for 15 minutes per day for three consecutive days. After the treatment, both inmate groups displayed a reduction in their self-perceived aggression. The BAQ evaluates four dimensions of aggression: anger, hostility, verbal aggression, and physical aggression. Aside from the non-murderer group failing to show a significant reduction in hostility, both groups displayed significant reductions in all dimensions of aggression.

Molero-Chamizo plans to follow up this study with one that includes a few improvements to the procedure in order to address some of the limitations from the first study. The initial study was only single-blinded and the control group consisted of prisoners that received no tDCS. For the following study, Molero Chamizo plans to include the university’s psychology students in the participant pool as well as acquiring saliva samples to measure cortisol levels before and after the tDCS treatment. Cortisol is an indicator of stress and could possibly suggest some aspect of aggressiveness. He also aims to examine the long-term effects of this particular type of tDCS treatment.

Both Andrés Molero-Chamizo and Joe Vukov’s work present two different aspects of neuromodulation.  The article by Molly J. Crockett that the class read in preparation for Joe Vukov’s talk deals with the question of how brain chemistry affects morality. Throughout her essay, she presents evidence indicating that our moral judgements are not fixed, but malleable. Although we typically view our moral judgements as inherently personal, distinctive, and indicative of who we are as people, they are often affected by neuromodulator levels, stress, hunger, and so forth. Joe Vukov’s presentation dealt with very similar questions. Although we see our moral intuitions as intrinsic, inborn elements of ourselves, they are undoubtedly shaped and cultivated by our particular upbringing. It’s easy to imagine that you’d have very different political or religious beliefs depending on what part of the world you were born in or to what type of parents you were brought up with, even though we see our political and religious beliefs as a reflection of our moral character. Following the same path, Molero-Chamizo’s work provides a more concrete example that morality is not fixed. Reducing aggressiveness certainly does not entail moral goodness, but this study does have an underlying goal of finding a possible avenue for reducing instances of violent crime, which is embedded in morality.

This type of work can have major implications. Societies are structured around a shared moral code, but we are now finding evidence that our moral intuitions can be tinkered with. Research such as this brings with it a collection of ethical questions regarding neuromodulators’ effect on moral judgments and whether it should be permissible to dabble with another’s moral inclinations.



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