Wednesday, February 28, 2018

Gaining a Better Understanding of Bipolar Disorder Thanks to FMRI in Children

Rocco DiCintio
Picture this; you are in a crowded space. There is not much room to move in either direction. In fact, you are being told to move as little as humanly possible. On top of all that, this place is also extremely noisy. Although the scene just described may seem like it were taken out of your most recent nightmare, it is in fact the uncomfortable reality that many people experience when they are sent to have an MRI done. Speaking from personal experience, I can attest to the uncomfortable nature of an MRI machine. Now, imagine how difficult it would be to get a young child to enter and stay inside one of these machines. If you can convince the child to enter the machine, then the child must also refrain from any major movement for minutes at a time. More specifically, fMRI studies conducted with young children require the children to stay relatively still in order to produce usable data. After learning about all the possible difficulties that come along with fMRI studies involving children, one may wonder “Why bother conducting these experiments?”. 
After further research, the benefits of conducting this type of research quickly become evident.
            One specific lab used an fMRI study with children to examine the different ways in which Bipolar disorder affects the brains of adults and children. This study, conducted by individuals associated with Bradley hospital, used data accumulated from one hundred fMRI studies. The goal of this study was to gain a better understanding of the neuronal mechanism that allows for the development of Bipolar disorder. The participants in these studies were both adults and children. Some of the data these researchers were analyzing came from studies that gathered data from face recognition fMRI studies. After reviewing the data collected, researchers found a striking difference between the brain activity of the adults and the brain activity of the children. More specifically, the data showed that there was greater activity in amygdala in bipolar youth when compared to bipolar adults.
            The team of researchers at Bradley hospital also examined data from studies that involved exposing participants to emotional stimuli. The result of these studies once again pointed to a greater amount of brain activity in the children. More specifically, greater activity in the inferior frontal gyrus was recorded for the children who participated in this study. When children were exposed to non-emotional cognitive tasks they showed a decreased level of activity, in comparison to adults, in the anterior cingulate cortex. The results collected from these multiple studies allowed the researchers at Bradley hospital to uncover specific areas of the brain that are either over-active or under-active in children who suffer from Bipolar disorder. The information gathered from this research has now prompted the researchers at Bradley hospital to conduct further research. This new research is aimed at developing a brain-based treatment for Bipolar disorder. As of now, the researchers believe that treatments that target emotional face identification may prove to be most effective. Treatment options being considered include computer games, titled “brain games”, as well as individual and group therapy.
            This research is extremely important because it seeks to find a solution to alleviate some of the symptoms of Bipolar disorder. Research has shown that many adults who suffer from Bipolar disorder have reported that they first began suffering from this disorder at a young age. For this reason, it is important to develop some sort of treatment that can alleviate the symptoms of Bipolar disorder at a young age. Bipolar disorder takes a great toll on the lives of children and adults each and every year. This disorder can affect all areas of an individual’s life, including their professional, social, and familial relations. Thanks to methods such as the utilization of fMRI studies with children, brain based treatment for bipolar disorder is now closer than ever.

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