Wednesday, May 2, 2018

Alzheimer's Disease: New Research in Screening and Treatments

Dr. Roy, a medical scientist studying Alzheimer’s disease at the University of Wisconsin Madison, recently drove down to Chicago to talk about his incredible new research into the exact mechanism of the disease and how researchers might go about actually utilizing this information.  Alzheimer’s disease is a degenerative disease which most often occurs during middle or old age, and up to this point, there has been no easy and cost-effective way to successfully identify this disease and the extent to which it might occur, nor have there been any major breakthroughs in an effective treatment that doesn’t involve the ever-popular “diet and exercise” method.  Alzheimer’s disease is physiologically identifiable post-mortem through an examination of the brain tissue, but is also signaled in living people by the unusually high levels of beta-amyloids in the brain and cerebrospinal fluid.
Dr. Roy’s approach utilizes the popular CRISPR/Cas9 technology, which he is trying to use to modulate this beta-amyloid production.  CRISPR/Cas9 is particularly popular among researchers because of its ability to actually edit DNA and subsequently alter what proteins the genome can produce.  While less than 10% of Alzheimer’s cases are believed to be inherited, this method is still valuable to edit mutations that might have arisen due to natural errors in genome copying and maintenance.  This potential treatment would target an amyloid precursor protein -- a protein that is responsible for generating such large amounts of beta-amyloid fragments -- and aim, in a one-time procedure, to effectively “turn off” the pathway for beta-amyloid creation.  This treatment is a long way off, but seems to be a promising possibility for Alzheimer’s disease in the future.
However, one problem remains: how do we know who actually has Alzheimer’s disease?  In America, 10% of people aged 65 and older are affected by and 32% of people aged 85 and older have the disease.  Currently, there are two ways to test for the disease by measuring the amount of amyloids in a living body: positron emission tomography (PET scans) and lumbar punctures.  PET scans are cost-prohibitive and lumbar punctures come with a host of risks, including infection and paralysis. Neither are realistic for mass screenings, which, with the sheer quantity of the population being affected, would be optimal.  Mass screenings would be an ideal way to determine who needs a treatment if technologies like Dr. Roy’s actually work. An article published by Scientific American details a promising and inexpensive new way to test for these amyloids that are caused by Alzheimer’s.  The researchers studying this thought outside of the box and tried to detect amyloids in a place we don’t currently look for them: the blood.
These researchers, based in Japan, believe enough amyloids making it through the blood-brain barrier to be able to effectively test for them with a simple blood test.  This test, if successful, would not only provide a much cheaper and safer alternative to traditional Alzheimer’s testing, but would even be able to help in distinguishing between Alzheimer’s and other forms of dementia in patients experiencing symptoms.  Their blood test is based on a technique called immunoprecipitation with mass spectrometry, which uses specific antibodies to bind and identify specific proteins. In this case, the protein being bound is the amyloid protein.
Amazingly, this blood test is something that’s already in clinical testing stages.  In a controlled trial setting which included 121 people from Japan and 252 people from Australia and individuals with normal brain function ranging all the way to severely impaired by the disease, it was found that the amount of amyloid present in the blood did, in fact, correlated with the degree of cognitive impairment.  The group conducting the research is currently trying to expand to other parts of the world and reach a larger audience in order to generate a better dataset for the amyloid concentration to Alzheimer’s impairment ratio.
Ultimately, treatments like Dr. Roy’s would be most effective if combined with wide-spread, cost-effective and non-invasive screening measures such as the one being researched by the Japanese group.  While the implementation of either is a long way off, the research being done on them now could help generate new ideas and produce more novel medical technologies.


Stetka, Bret. “A Big Step toward a Blood Test for Alzheimer's.” Scientific American, 31 Jan. 2018, www.scientificamerican.com/article/a-big-step-toward-a-blood-test-for-alzheimers/.

The physical approximation of APP and BACE-1: A key event in Alzheimer's disease pathogenesis. Jichao Sun and Subhojit Roy*
Developmental Neurobiology 2017 Nov 6. doi: 10.1002/dneu.22556.

13 comments:

  1. Alzheimer's illness is common in my family, I have been stressed at work for at least 16 years suffered depression my thoughts were blocked. So I knew the need to keep a watch on it, that was when I began to walk several times a week, 2 miles a day and realized that was a positive thing, but it got to a point my whole body started getting weaker, I needed some help. I started up training, the trainer came to my hometown 5 times a week and he told me that would be able to help me. I agreed with him and was happy I finally found solution not until I woke up one day and couldn't walk. Tried out so many medications and diet but none of them was able to help me. In the process I knew about ZOMO, an herbal medicine for Alzheimer's disease, I followed the blog address shared; I curiously contacted him and got ZOMO. I didn’t want to be disabled at my old age, and was so hungry for more healthy days on earth. My recovery involved both medicine and diet. I never had any complications I experienced while on English medications why using ZOMO. You may contact Dr. Charanjit via his email. charantova@gmail.com or visit his blog via curetoalzheimer.blogspot.com

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  2. The molecular weight of amyloid β-protein (Aβ) is about 4kDa, which is hydrolyzed by β-amyloid precursor protein (APP) and secreted by cells. It has very strong neurotoxic effect after sedimentation in cell matrix. β-Amyloid Fragments

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  3. 3d bioprinting = Immortality = go to stars ((typewrite: interstellar travel constant acceleration))

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  4. ...3d bioprinting-Immortality (mom-printer: not euthanasia)… within 1 century, to die will be "out of fashion"... whereas there is Life there is hope for hook to 1st Immortal Generation… There is not another life in none "life beyond" of religion´s lies. The unique Immortality it is coming from We self: Technological Immortality...modified BIOLOGICAL TIMERS...3D BIOPRINTING... on wake up, but...if I am, when I was 18 years old...and still so I remember all my life in the ancient body before…(that is the important: REMEMBER the previous lives after each mortal accident, not remember will serve of nothing because then always you will be living 1 only time without know it)… On the body the important is the head, in the head the important is the brain, in the brain the important is...The Memory...which is, along with Genes and Image, simply, what we are... Your recorded Memory to the new young perfect identical Bioprinted Body and...Immortality...already the accidents do not matter. The Memory is the "soul" (software), our body only is the "automobile" that transport us (hardware)… To what extent are we willing to recognize a friend, or picture yourself, who has received an orthopedic implant after an accident?. Until 1 leg?, besides of leg the 2 arms?, besides of this the chest?, besides of this...where until we still considering to it the same person?... (it´s me!, it´s me!...we would shout without voice, only with head and an extracorporeal machine, on hear to them saying…"well already we must disconnect to it"). Ultimately, already outside from the physical body, the Memory remains… Wherever our Memory goes, we go away with her… Record the Memory in a electronic format and stored by Law in the Official Data Banks, along with Genes and some Photos of each one, waiting there are in the Future... 1: BIOPRINTED BODIES genetically identical, in image and in all, to the originals in which "revitalize" to the electronic sleepers… 2: SPACE where to live a New and Immortal Life in some Universe´s habitable place… We do not can claim stay all ones here, besides each star and planet they have "expiration date"... "Earth is the cradle of the reason, but is impossible to live eternally in a cradle" (Konstantin E. Tsiolkovski)… ((But...is that…"it" already would be not "Me" of "black paw´s ham"...it would be a "cyborg/clone/avatar/frankenstein"... Are you sure?, because to sleep, lose consciousness, "it" of "black paw´s ham" dies and disappears every night (die=sleep=fall fainted: switch off and darkness...the unique difference is when sleeping the body continues horizontal living alone vegetal without us, how an empty house no owner occupied)...and on wake up "it" appears every morning (rebirths)...and our MEMORY instantly auto-recognize us, the same in our own original body which in our new body (new car eh!)… If we would have lost the Memory...we would have lost the Life))… Have to accelerate Research about Memory and the Space´s Colonization… Immortality comes... Memory-Genes-Photo>>Bioprinted Body>>Space...

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  5. Hiv disease for the last 3 years and had pain hard to eat and cough are nightmares,especially the first year At this stage, the immune system is severely weakened, and the risk of contracting opportunistic infections is much greater. However, not everyone with HIV will go on to develop AIDS. The earlier you receive treatment, the better your outcome will be.I started taking ARV to avoid early death but I had faith in God that i would be healed someday.As a Hiv patent we are advise to be taking antiretroviral treatments to reduce our chance of transmitting the virus to others , few weeks ago i came on search on the internet if i could get any information on Hiv treatment with herbal medicine, on my search i saw a testimony of someone who has been healed from Hiv her name was Achima Abelard and other Herpes Virus patent Tasha Moore also giving testimony about this same man,Called Dr Itua Herbal Center.I was moved by the testimony and i contacted him by his Email.drituaherbalcenter@gmail.com OR info@drituaherbalcenter.com. We chatted and he send me a bottle of herbal medicine I drank it as he instructed me to.After drinking it he ask me to go for a test that how i ended my suffering life of Hiv patent,I'm cured and free of Arv Pills.I'm forever grateful to him Drituaherbalcenter.Here his contact Number +2348149277967...He assure me he can cure the following disease..Hiv,Cancer,Herpes Virus,Hpv,Pile,Weak Erection,Lyme Disease,Epilepsy,Glaucoma.,Brain Tumor, Cataracts,Macular degeneration,Cardiovascular disease,Lung disease.Enlarged prostate,Osteoporosis.Alzheimer's disease,
    Dementia. ,Bladder Cancer,Colorectal Cancer,Breast Cancer,Kidney Cancer,Leukemia,Lung Cancer,Non Hodgkin Lymphoma,Skin Cancer,Lupus,Uterine Cancer,Prostate Cancer, Seizures, fibromyalgia ,ALS,Hepatitis,Copd,Parkinson disease.Genetic disease,Fibrodysplasia disease,Fibrodysplasia Ossificans Progressiva,Fluoroquinolone Toxicity Syndrome,Stroke,Hpv,Weak Erection,Liver/Kidney Inflammatory,Men/Woman infertility, bowel disease ,Huntington's disease ,Diabetes,Fibroid...

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  6. DOES HERBS WORK FOR DEMENTIA?

    This was the same question that prompted me to read further a testimony I saw on a blog. I would like to tell a story - hoping it will be useful to others - of my struggles and achievements with Dementia. I was diagnosed a little over 4 years ago, No doctors I met have any treatment or even suggestions apart western medications. I even sought advice on Youtube, to no avail. After using the conventional approach to medication treatment without improvement. I am glad something happens fast. There have been suicides due to people not being able to continue on living with the endless memory challenges. It is horrible. I learned about Dr. charanjit herbal medicine that works effectively for me without any negative effects. I have returned back to my normal life and I hope that the symptoms do not return again, It really helped me! If you have Dementia kindly contact Dr. Charanjit for help and necessary solution (charantova@gmail.com)

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  7. Wow! This could be one of the most useful blogs we have ever come across on Actually excellent info! I’m also an expert in this topic so I can understand your effort. Brainfort supplement

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  8. I have decided to make this post or testimony public. My husband was diagnosed with Alzheimer’s ten years ago. I loved my husband very much, and it was heartbreaking to have him develop Alzheimer's disease, and to stand by and watch him decline in his ability to take care of himself, struggling with day-to-day tasks. It takes away his memory and eventually the ability to do basic tasks. Alzheimer’s doesn’t just affect the person who is diagnosed — it also turns your world as caregiver, upside down if your loved one is grappling with the condition. To be clear, there is no pharmaceutical medicine, no magic pill that have any significant effect on the progressive downhill course of this disease. Not until we use an Herbal Medicine called BRONGEE that put an end to it. He has been well and living his best life. While there may be other different option to into. Never make your own success path a secret. There should be no shame. Contact Dr Rohan with dr.rohanronjohn@gmail.com, It may also help you too.





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  9. I have decided to make this post or testimony public. My husband was diagnosed with Alzheimer’s ten years ago. I loved my husband very much, and it was heartbreaking to have him develop Alzheimer's disease, and to stand by and watch him decline in his ability to take care of himself, struggling with day-to-day tasks. It takes away his memory and eventually the ability to do basic tasks. Alzheimer’s doesn’t just affect the person who is diagnosed, it also turns your world as caregiver, upside down if your loved one is grappling with the condition. To be clear, there is no pharmaceutical medicine, no magic pill that have any significant effect on the progressive downhill course of this disease. Not until we use a Herbal Medicine called BRONGEE that put an end to it. He has been well and living his best life. While there may be other different option to into. Never make your own success path a secret. There should be no shame. Contact Dr Rohan with dr.rohanronjohn@gmail.com, It may also help you too.

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  10. Most people around the world do not believe there is cure for Alzheimer's/dementia talk more of herbal cure. After my father was diagnosed of Alzheimer's, all modes of medication including donepezil (Aricept), rivastigmine (Exelon) and galantamine (Razadyne) couldn't help treat him until I came across an article online about Dr Rohan and his herbal exploit in treating and curing Alzheimer's. I contacted him regarding my father's situation and he assured me my father will be cured using herbal medicine. We acquired his herbal medicine out of desperation to cure my father, lo and behold I started seeing positive results in my father just about 3 week and what amazed me the most was that by the 12th week my father became completely cured and OK beyond my imagination after all necessary test confirmation. Believe it or not I have seen it all there is herbal cure for Alzheimer's that is more potent than any medication or treatment. If you have Alzheimer's I advise you opt for herbal cure by contacting Dr Rohan on dr.rohanronjohn@gmail.com you shall come here to testify just like me. Believe it or not I have pass the information for awareness.

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  11. My mom was diagnosed with Alzheimer's disease 7 years ago, almost when all hope was lost due to several failed attempts in making her healthy. My desire to see her permanently free drives me into searching the internet for possible solutions which led me to a video about Alzheimer’s disease on YouTube, I met with a comment about herbal medication and how an herbal doctor used herbs to cured someone of Alzheimer's Dementia. I usually do not believe in herbal medications but I had to give it a try for the sake of my dying mother. I collected the herbal doctor's contact and reached out to him, we talked about it and he asked few questions about her physical challenges and her previous medical treatment report which I provided the details, and then he prepared the herbal medicine and sent them to me here in Tennessee with prescriptions on how to use it attached to it and I ensured my mom took the herbal medicine accordingly and within 3 weeks of using this medication, we started seeing improvement in her health condition and now, I am very happy to share this testimony that my mom is permanently cured of this horrible disease called Alzheimer and I encourage everyone suffering from one sickness or the other not to lose hope for there is no sickness without cure if the right medication is applied. Dr. Rohan can cure several sicknesses including; Herpes, Influenza, Fibroid, PTSD, Diabetes, Cancer, STDs, etc.. you can contact Dr. Rohan for your herbal cure of whichever sickness that is threatening your peace through his email; dr.rohanronjohn@gmail.com  

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  12. I can’t forget in a hurry my Mom's horrible years of fight with Mental ailment (Alzheimer). My Mom got really sick around Christmas that year. When I saw her in the hospital with all those tubes, I just lost it. I got so hysterical that I had to be escorted out. Soon after that, I got into that altercation with my neighbor and was sent to jail. When I got out of jail, Her symptoms were acting up and I felt so angry.  Dad had already taken her to a state psychiatric hospital. I was really nervous, but I talked to a psychiatrist there who made me feel comfortable. For the first time, she opened up about what she was experiencing—the voices, not being able to remember things, the paranoia. She said, “Your mom is battling Alzheimer.” I didn’t even know what that meant.

    He suggested that when she got out of the hospital and off the treatments she was taking there, we try a new treatment for Alzheimer. After weighing the risks and benefits, we both agreed the treatment, given through monthly injections, might help control her symptoms. Meanwhile, I made friends, and gained insight into her illness. During the week, there were movies, cooking classes and education sessions about her disease—basically, activities to help people like her get back into society. I learned about Alzheimer and what some of her triggers were. All told, she stayed there for two months and we left, I was taking her for doctor’s appointments and grocery shopping. It was hard, especially when her birthday passed, I still helped her walk, fix her food and dress her which made me sad because she was very active at 69 until the illness struck her.

    I came across a herbal medication sometimes last year called zomo but before we started the treatment, we started a day rehabilitation program, and also started the new medication with zomo. I was working hard to achieve my care goals by following the treatment plan. Her symptoms got under control within three months, as she started feeling better. First she regained interest in the things she used to enjoy, like calling/visiting our family and friends for lunch and going for walks in the park and grocery shopping. I will never forget what I went through, or what it took for her to get here. I don’t take any of it for granted. I consider myself an advocate for people who don’t have any knowledge about this herbal medicine. To anyone who’s taken the time to read this that may be struggling with this awful ailment (Alzheimer), reach out, share, I guarantee you reach out to charantova@gmail.com, and know, that as lonely as you may feel, as hopeless as you believe things are, please know, that there are so many patients out there going through same and you are never alone! reach out to him so you could share your own testimony to let others know there is hope.

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