According to the Mayo Clinic, Alzheimer's Disease with an early onset affects around 200,000 Americans, and is characterized through its symptoms in people only under the age of 65. The paper "Early Alzheimer’s disease blocks responses to accelerating self-movement" and talk "Cortical responses as markers of aging and Alzheimer’s disease" by Dr. Fernandez as well as the New York Times article "Frequent, Brisk Walks May Aid Those With Early Alzheimer’s" discuss the relationship between Early Alzheimer’s disease and physical movement. Dr. Fernandez's paper established that Early-Onset Alzheimer’s disease has serious implications for people who had it to drive safely due to the deterioration in processing one's own movements. The New York Times article "Frequent, Brisk Walks May Aid Those With Early Alzheimer’s" discussed the publication in PLoS One that discovered patients in the early stages of Alzheimer's Disease who had engaged in "frequent, brisk walks," were found to have decreased the progression of the disease. Dr. Fernandez's talk mostly focused on the development and presence of amyloid beta plaques in brain in Alzheimer's Disease, such was the basis of his research on self-movement processing. University of Kansas' researchers in the paper "Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial" discussed how previous research established how more fitness was positively correlated with moderating the effects that amyloid beta plaques had on the brain. The neuroscience research on the relationship between self-movement and Alzheimer's disease in the context of early-onset or in the early stages of the disease has important implications for the future of healthcare and medicine in the United States. Considering the severity of Alzheimer's Disease and the psychological and physical toll that losing awareness of one's motor movements subsequently has on a person, the consequences of this research cannot be overstated.
In the paper "Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial," the researchers enrolled patients still in the early stages of Alzheimer's disease to participate in exercise centered around walking in the hopes of improving cardiovascular fitness (as well as had a control group that mostly engaged in light exercise that did not attempt to increase cardiovascular fitness) and found that bilateral hippocampal volume increased as well as memory performance in the group engaging in cardiovascular fitness. As Dr. Fernandez's previous research established, early onset Alzheimer's detrimentally affects processing of one's own movement, so research indicating that a relatively affordable, simple treatment such as implementing light exercise could possibly mitigate and reduce such a negative effect on the patient is welcome news. I wonder how the participants from the study after having participated in the exercise program would fare in an experiment similar to the one Dr. Fernandez conducted in his paper "Early Alzheimer’s disease blocks responses to accelerating self-movement." Although memory and hippocampus volume increased, I wonder if the benefit from the exercise would be marginal enough to mitigate Early Alzheimer's Disease's effect on the optic flow N200s' amplitude. Dr. Fernandez's experiment indicated that the decreased performance of participants in regards to self-processing of movement was also due to the lack of variance in response to changes in speed increments of stimuli. In that case, it would be interesting to see what the effect that the exercise regime had on sensitivity to changes in speed increments of the stimuli used in Dr. Fernandez's experiment.
Dr. Fernandez's research mostly focused beta amyloid plaque buildup had on the progression of Alzheimer's Disease. and on the issue of processing as affected by early-onset Alzheimer's disease in the context of the implications it had for driving. Dr. Morris, who led the study on exercise and Alzheimer's Disease, noted that many of the participants hadn't actually gained much physical endurance, so it would not be hard to logically conclude that the gains in physical function and memory were not great enough to challenge the threat that the onset of Alzheimer's Disease had for participants to continue their driving. Although Dr. Morris' bold new research bodes exciting possibilities for the development of potential ideal exercise plans for those diagnosed with Alzheimer's Disease, it does not seem currently strong enough to suggest that Dr. Fernandez's concerns about the implications of Alzheimer's Disease on the ability of a patient to continue to successfully and safely drive.
Works Cited:
Frequent, Brisk Walks May Aid Those With Early Alzheimer’s
https://www.nytimes.com/2017/03/01/well/move/frequent-brisk-walks-may-aid-those-with-early-alzheimers.html
Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170547
Early Alzheimer’s disease blocks responses to accelerating self-movement
https://loyolauniversitychicago-my.sharepoint.com/personal/rmorrison_luc_edu/Documents/Forms/All.aspx?slrid=d35c639e-5053-5000-f96f-83ea585b54a1&FolderCTID=0x01200052F973E683B96F4F97B49148A837C07C&id=%2Fpersonal%2Frmorrison_luc_edu%2FDocuments%2FNEUR%20300%2F%2803%2E27%2E18%29%20-%20Roberto%20Fernandez-Romero%2FNBA2012%2Epdf&parent=%2Fpersonal%2Frmorrison_luc_edu%2FDocuments%2FNEUR%20300%2F%2803%2E27%2E18%29%20-%20Roberto%20Fernandez-Romero
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