In the article, “Endocytic Vesicle Rupture is a Conserved Mechanism of Cellular Invasion by Amyloid Proteins,” the researchers, Flavin et al, research how amyloid proteins spread from cell to cell and rupture intracellular vesicles during neurodegenerative diseases. The researchers found that different types of WT or familial α-synuclein can induce vesicle rupture. Ruptured vesicles can then fuse into large intracellular structures resembling Lewy bodies, which in brain structures from Parkinson's disease patients, there are the same vesicle rupture markers surrounding Lewy bodies. The results illustrate how vesicle rupturing plays an important part in the spread of amyloid assemblies associated with neurodegenerative diseases and the formation of Lewy bodies.
In the article, “For Some Parkinson’s Patients, Boxing Can Be Therapy,” the author, Rachel Fairbank, discusses how a woman with Parkinson’s has started no-contact boxing training and the positive effect it has had on her disease. The balanced stance that boxers take has helped many patients with their balance and prevented them from falling, a very common symptom of Parkinson's disease. Other symptoms boxing can help improve or slow the effects of are coordination and agility. No-contact boxing allows people to be active and get the benefits of boxing without being injured or getting concussed, which can increase a person’s chance of Parkinson’s.
Learning the mechanisms behind Parkinson’s along with ways to help treat it besides medicine, can help researchers better understand and treat the disease. There could be studies done to discover the mechanisms behind how exercise affects vesicle ruptures, amyloid proteins, and Lewy bodies. Ultimately, able patients should stay active to slow their symptoms' effects.
Resources:
Fairbank, R. (2022, May 23). For some Parkinson's patients, boxing can be therapy. The New York Times. Retrieved December 14, 2022, from https://www.nytimes.com/2022/05/23/well/move/parkinsons-boxing-therapy.html
Flavin, W. P., Bousset, L., Green, Z. C., Chu, Y., Skarpathiotis, S., Chaney, M. J., Kordower, J. H., Melki, R., & Campbell, E. M. (2017). Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins. Acta Neuropathologica, 134(4), 629–653. https://doi.org/10.1007/s00401-017-1722-x
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