Tuesday, December 11, 2012

Sightless Dementia and the Future of Neuroprosthetics



The human mind, a labyrinth of curvatures and intricacies conducting an orchestra with every impulse sent and received. As the crescendo fades and neurodegenerative disease progresses, the synchronous melodies grow fainter, yet vague resonances persist.  The arrangement of memories, perceptions and thoughts are composed from a lifetime of visual stimuli and for patients who suffer from different types of dementia, art helps to manifest remnants of their experiences. 

According to behavioral neurologist, Dr. Bruce Miller, art draws on different cognitive areas and processes within the brain and while behavioral and emotional deficits occur there is a component of visual creativity which can emerge, be enhanced or decline.  He asserts the importance of understanding visual creativity in dementia as a tool for unlocking the brain areas activated by artistic processes and can aid in rehabilitation of such patients.  Dr. Miller’s research has led to the realization that artistic creativity varies among the different types of dementia patients. For example, a patient suffering from frontotemporal dementia can copy images without problems, but someone with Alzheimer disease struggles with a copying task.  
 
Dr. Miller explains that artistic creativity in dementia patients comes from a “ventral stream involved with the recognition of ‘what’ is seen, and a dorsal stream that localizes ‘where’ an item has been perceived and these visual scenes are absorbed throughout a lifetime.”  People with dementia begin to unravel their woven tapestries of objects, landscapes, and people through paintings and drawings.  Clearly, Dr. Miller’s focus was on patients who had vision, but what about blind and visually impaired people who suffer from dementia.  For some dementia patients vision declines as the disease progresses, and others may have been blind and developed dementia later in life.  Some studies suggest links between Alzheimer disease and nerve damage in glaucoma. There are associations between reduced vision and hallucinations in dementia patients and studies have pointed to the therapeutic value of helping to improve their vision.  
 
Grid of electrodes implanted on retina 

A breakthrough in neuroprosthetics may prove helpful for blind dementia patients.  Researchers at Second Sight Medical Products have devised a new retinal implant where words are stimulated directly onto the retina.  The device uses a small camera attached to eyeglasses which sends input to a portable processor.  The processor translates the signal from the camera to a microchip with electrodes that is implanted on the retina.  The remaining retina cells are stimulated and electrical impulses are transmitted down the optic nerve conveying visual information to the brain. The brain perceives the pattern of light and the patient learns how to interrupt the visual patterns.  

So far, the device has been implanted in 50 patients and reports indicate that some see color, movement and objects. However, the device does not give a full sense of what is around the person; rather it grants a rough idea of their surroundings.  Reading Braille is also possible and achieved without any sensory input like touch.  Researcher, Thomas Lauritzen explains that, “patients could see the patterns projected and then read individual letters in less than a second with up to 89% accuracy.”  Patients with the device have the ability to read up to four letter words, which proves that patients had good spatial resolution because they could easily distinguish signals on individual electrodes.

          The Argus II is primarily for sufferers of Retinitis Pigmentosa, however it may help other conditions of sightlessness such as glaucoma which is evident among some dementia patients.  Professor and researcher, Silvestro Micera at EPFL’s Center for Neuroprosthetics explains, “this study is proof to the importance of clinical experiments involving new neuroprosthetic devices to improve the technology and innovate adaptable solutions.” The Argus II is absolutely revolutionary and as studies and technologies advance so will the scope of what neuroprosthetics like the Argus II can do for visually impaired and blind people.  The future prospects of such devices should give hope to researchers like Dr. Miller who probably find it difficult to treat blind dementia patients.

http://www.sciencedaily.com/releases/2012/11/121122095433.htm

http://www.ncbi.nlm.nih.gov/pubmed/15210520

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