I could draw many parallels between Dr. Hui Ye’s study of Stem Cell Galvanotaxis and Dr. Robort Babon-Philipos’ study of how direct-current electric fields induce rapid and directed cathedral galvanotaxis of adult Subpendymal Neural Precursor Cells. Dr. Ye had mentioned that neural stem cell transplantation had become an increasingly preferred solution for injuries and diseases affecting the central nervous system.
He also emphatically underscored the fact that one of the key impediments to this type of therapy being successful is that the transplanted cells may not necessarily migrate to the desired area.
Dr. Ye explored the notion of exposing these stem cells to an electric field which is predicted to stimulate their migration. The electric field that the cells encountered was a direct electric field. He has solidified the underpinnings of the study by constructing biophysics models which simulate interactions between the electric field and the cell.
His gained a numerical understanding about such aspects as field-induced cell polarization under a direct current electric field. To ensure success in this therapy, Dr. Ye utilized a technique better recognized as a patch-clump technique to the cell in the field.
The success of both neural stem cell harvesting and culturing techniques manifests that an electric field can stimulate migration. This study is intended to operate as a “stepping stone” for future scientific investigations which intend to use electric field stimulations as a form of treatment for neurological diseases and injuries.
Such a conundrum was faced by Robart Babona-Pilipos when she wanted to look into migration of subependymal zone neural stem cells (better known as NPCs) and their progeny to lesioned regions of the brain of mice. She looked to this as a panacea for cortical injury.
Babona-Philips believed that endogenous NPC’s within the forebrain of an adult person can be activated to grow and move to the site of damage where they can differentiate into neural cells. In order to better attain the precursor migration to advance the repair process, Philips utilized an externally applied electrical current.
This led her to discover that direct current electric fields (better known as DCEFs) induced galvanotaxis of pure populations of undifferentiated adult mouse subepednyma-derived NPCs.
In her study, she found that undifferentiated NPCs undergo random migration in all directions at a velocity of .23 plus or minus .12 micrometers per minute and a directedness of .12 plus or minus .07. In the presence of DCEFs, the very same undifferentiated NPCs exhibit a four fold increase in the velocity of migration as well as a nine fold increase in cathodal directedness. The new velocity was found to be 1.09 plus or minus .05 micrometers per minute and the directedness around .96 plus or minus .01.
From looking at Dr. Ye and Dr. Babona-Pilipos’s experiments it is obvious that Direct Current Electric Fields induce migration of neural stem cells and endogenous cells within the brain. Because of these successes, future research endeavors should take into account such an asset for therapy of neural conditions.
Babona-Pipipos, Robart, Droujinine, Ilia, Morshead, Cindi M Direct-Current Electric Fields Induce Rapid and Directed Cathodal Galvanotaxis of Adult Subependymal Neural Precursos Cells<
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